The concomitant usage of opioids with other medicines that have an affect on the serotonergic neurotransmitter technique has resulted in serotonin syndrome.
The next laboratory tests could possibly be affected in clients that are receiving therapy with promethazine hydrochloride.
patients who are allergic to promethazine, any of your ingredients in promethazine, or to other phenothiazines
The next critical adverse reactions are described, or described in higher element, in other sections:
Usually do not consider any benzodiazepines or medicines that might cause drowsiness or sleepiness during treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Remedy. Request your healthcare provider for a list of these medicines if You're not sure.
Codeine may possibly increase the neuromuscular blocking action of skeletal muscle relaxants and generate an elevated diploma of respiratory depression.
Lower Seizure Threshold - Promethazine may well reduced seizure threshold. It ought to be employed with warning in persons with seizure Conditions or in persons who're applying concomitant drugs, such as narcotics or regional anesthetics, which can also have an effect on seizure threshold.
Very low blood pressure. A unexpected fall in blood pressure can transpire in many people during treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Solution and this may perhaps trigger you to definitely really feel dizzy, faint, lightheaded, or weak, particularly when you stand up (orthostatic hypotension). Your threat of getting this issue may very well be amplified if you take Promethazine Hydrochloride and Codeine Phosphate Oral Option with sure other medicines that reduced blood pressure.
are Expecting or strategy to be pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Answer can hurt your unborn child. See “What's The most crucial information and facts I need to know about Promethazine Hydrochloride and Codeine Phosphate Oral Option?” are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and could potentially cause critical Negative effects in your newborn which includes amplified sleepiness, breathing challenges (respiratory depression), and Loss of life. It is not identified if promethazine can move into your breast milk.
Anaphylactic reactions, as adjunctive therapy to epinephrine and also other conventional measures, following the acute manifestations happen to be controlled.
Promethazine is an antihistamine that may be taken by mouth being an oral Remedy or tablet, rectally as a suppository, or by injection. It can be employed for:
Pediatric sufferers must be supervised to stay away from potential harm in bike riding or in other hazardous actions.
Respiratory melancholy bringing about arrest, coma, and Loss of life has happened with the use of codeine antitussives in younger children, specially within the underneath-1-12 months infants check here whose ability to deactivate the drug is just not fully designed.
Bodily dependence, the situation in which ongoing administration in the drug is required to circumvent the appearance of the withdrawal syndrome, assumes clinically major proportions only soon after quite a few weeks of ongoing oral opioid use, Despite the fact that some gentle diploma of physical dependence may perhaps produce following a couple of days of opioid therapy.